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KMID : 0388019940050040023
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Korean Journal Gynecologic Oncology and Colposcopy
1994 Volume.5 No. 4 p.23 ~ p.28
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Expression of the mutant p53 gene in the careinoma of the cervix uteri
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권경익
이태성/이정호/차순도/이상숙/서영옥
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Abstract
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The nuclear accumulation of p53 protein is Known to correspond with mutation of the p53 tumor supressor gene.
To investigate the relationship between clinico-pathologic features and expression of p53 mutations, 65 cases of primary cervical carcinoma were analysed by an immunohistochemical method using monoclonal antibody of p53.
Immunostaining demonstrated various nuclear stinings of cancer cells in 48.4T of squamous cell carcinoma(51.9% in large cell carcinoma and 25.% in small cell carcinomas) and 23.5% of adenocarcinoma. (p<0.05) No differences in clinical stage and
p53
positivity were found.
There was no significant correlation between p53 positive cases and status of recurrence.
This data suggests that p53 mutation plays an important role in carcinogenesis of the cervical cancer. The nuclear accumulation of p53 protein is not correlated with the disease progression and prognosis.
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KEYWORD
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